Targeted RNA

Delivery Through
Polymer-Lipid Hybrid

Targeted RNA

Delivery Through
Polymer-Lipid Hybrid

Next-generation polymer–lipid hybrid nanoparticles engineered for precise, organ-specific RNA delivery, driving safer and more effective therapies

Targeted RNA

Delivery Through
Polymer-Lipid Hybrid

Next-generation polymer–lipid hybrid nanoparticles engineered for precise, organ-specific RNA delivery, driving safer and more effective therapies

The Challenge

The missing link in RNA therapeutics

We already know RNA can transform how we treat disease.
What we don’t yet control is where it goes, how long it lasts, and how it behaves in the body. Until delivery is solved, much of this potential remains out of reach.

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Our platform

A platform for targeted RNA delivery

Precision Targeting

Engineered nanocarriers that target specific tissues and cell types with exceptional accuracy and minimal off-target effects.

Precision Targeting

Engineered nanocarriers that target specific tissues and cell types with exceptional accuracy and minimal off-target effects.

Precision Targeting

Engineered nanocarriers that target specific tissues and cell types with exceptional accuracy and minimal off-target effects.

Enhanced Safety

Biocompatible materials designed for optimal safety profiles and controlled biodegradation.

Enhanced Safety

Biocompatible materials designed for optimal safety profiles and controlled biodegradation.

Enhanced Safety

Biocompatible materials designed for optimal safety profiles and controlled biodegradation.

Tunable Surface Chemistry

Adaptable technology for precise nanoparticle surface control and diverse RNA applications.

Tunable Surface Chemistry

Adaptable technology for precise nanoparticle surface control and diverse RNA applications.

Tunable Surface Chemistry

Adaptable technology for precise nanoparticle surface control and diverse RNA applications.

The Technology

Hybrid Nanocarrier Technology

Hybrid Nanocarrier Technology

Hybrid Nanocarrier Technology

Therapeutic Applications

Programs Pipeline

01

Cardiac Regeneration

Expanding horizons for RNA therapy applications across multiple disease areas.

Lead Program

Preclinical (TRL 4)

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01

Cardiac Regeneration

Expanding horizons for RNA therapy applications across multiple disease areas.

Lead Program

Preclinical (TRL 4)

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01

Cardiac Regeneration

Expanding horizons for RNA therapy applications across multiple disease areas.

Lead Program

Preclinical (TRL 4)

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02

Neuromuscular Diseases

Precision RNA delivery to muscle tissue for the treatment of genetic and degenerative neuromuscular disorders.

Research (TRL 3)

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02

Neuromuscular Diseases

Precision RNA delivery to muscle tissue for the treatment of genetic and degenerative neuromuscular disorders.

Research (TRL 3)

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03

CAR-T therapy

Ex vivo RNA delivery to immune cells, advancing toward in vivo delivery strategies for hematologic cancers treatment.

Early research (TRL 2–3)

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03

CAR-T therapy

Ex vivo RNA delivery to immune cells, advancing toward in vivo delivery strategies for hematologic cancers treatment.

Early research (TRL 2–3)

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Future Therapeutic Areas

Expanding horizons for RNA therapy applications across multiple disease areas.

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Future Therapeutic Areas

Expanding horizons for RNA therapy applications across multiple disease areas.

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Who we are

Meet the Team

Led by a multidisciplinary team from Politecnico di Torino, combining expertise in pharmacology, biomedical engineering, and biotechnology.

Portrait of Letizia Nicoletti

Letizia Nicoletti, PhD

Chief Executive Officer (CEO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

Portrait of Letizia Nicoletti

Letizia Nicoletti, PhD

Chief Executive Officer (CEO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

Portrait of Giovanni Paolo Stola

Giovanni Paolo Stola

Chief Operating Officer (COO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

Portrait of Giovanni Paolo Stola

Giovanni Paolo Stola

Chief Operating Officer (COO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

Portrait of Valeria Chiono

Valeria Chiono, PhD

Chief Technology Officer (CTO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

Portrait of Valeria Chiono

Valeria Chiono, PhD

Chief Technology Officer (CTO)

Oversees operations, including nanoparticle production and quality control, ensuring alignment with preclinical development and TRL advancement. Supports business planning, budgeting, and fundraising, contributing to market analysis and product valorization

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Partner with us to advance

RNA therapeutics

We are actively seeking pharmaceutical and research partners to accelerate the development of our RNA delivery platform and bring innovative therapeutics to patients.

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Partner with us to advance RNA therapeutics

We are actively seeking pharmaceutical and research partners to accelerate the development of our RNA delivery platform and bring innovative therapeutics to patients.

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Partner with us

to advance

RNA therapeutics

We are actively seeking pharmaceutical and research partners to accelerate the development of our RNA delivery platform and bring innovative therapeutics to patients.

Advancing RNA therapeutics through innovative polymer-lipid nanoparticle technology.

Headquarters

Politecnico di Torino

Corso Duca degli Abruzzi, 24

10129 Torino, Italy

Follow Us

PoliRNA S.r.l. is a spin-off of Politecnico di Torino.
Partita IVA: 13019190019

© 2026 PoliRNA. All rights reserved.

Advancing RNA therapeutics through innovative polymer-lipid nanoparticle technology.

Headquarters

Politecnico di Torino

Corso Duca degli Abruzzi, 24

10129 Torino, Italy

Follow Us

PoliRNA S.r.l. is a spin-off of Politecnico di Torino.
Partita IVA: 13019190019

© 2026 PoliRNA. All rights reserved.

Advancing RNA therapeutics through innovative polymer-lipid nanoparticle technology.

Headquarters

Politecnico di Torino

Corso Duca degli Abruzzi, 24

10129 Torino, Italy

Follow Us

PoliRNA S.r.l. is a spin-off of Politecnico di Torino.
Partita IVA: 13019190019

© 2026 PoliRNA. All rights reserved.